Miranda Galvis, M., Santos-Silva, A.R., Jardim, J.F. et al. (8 more authors) (2018) Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients. Journal of Oral Pathology and Medicine , 47 (1). pp. 32-39. ISSN 0904-2512
Abstract
Abstract
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide and the clinical and behavioral characteristics of tumors in this group are controversial and the literature shows divergent results.
Purpose
To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤ 40 years old).
Methods
A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs. 71 cases of elderly patients) and submitted to immunohistochemical reactions with Ki67, p53, p16, Bcl-2, Cyclin D1, C-ErbB2, p21, Myc, EGFR, MMP-9, SMA, Cathepsin K and FGF-2 antibodies.
Results
Clinicopathological features and survival rates were similar in both groups. Although overexpression of EGFR (p = 0.042) and MMP-9 (p = 0.001) was more frequent in young patients, only C-ErbB-2 (p = 0.048) and SMA (p = 0.048) expression correlated with lower DFS in this group of patients.
Conclusion
Clinicopathological features and survival rates are similar between younger and older patients with OSCC. The different patterns of C-ErbB2, EGFR, MMP-9 and SMA expression between the groups merits further investigation to understand their role in the early tumor onset in young patients.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is an author-produced version of a paper subsequently published in Journal of Oral Pathology & Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Oral squamous cell carcinoma; cell cycle proteins; clinicopathologic characteristics; local invasion proteins |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jul 2017 11:57 |
Last Modified: | 18 Aug 2023 15:13 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/jop.12601 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:119107 |