Barker, E.D., Walton, E., Cecil, C.A.M. et al. (9 more authors) (2018) A methylome-wide association study of trajectories of oppositional defiant behaviors and biological overlap with attention deficit hyperactivity disorder. Child Development, 89 (5). pp. 1839-1855. ISSN 0009-3920
Abstract
In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7 to 13) of oppositional defiant disorder (ODD), and the ODD sub-dimensions of Irritable and Headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and Headstrong but not for Irritable. Overlap analysis indicated biological correlates between ODD, Headstrong and ADHD. DNA methylation in ODD and Headstrong was partially genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (Headstrong) and cigarette smoking (ODD and Headstrong).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Child Development published by Wiley Periodicals, Inc. on behalf of Society for Research in Child Development. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
Keywords: | ALSPAC; Oppositional Defiant Disorder; Irritability; Headstrong; Attention Deficit Hyperactivity Disorder; DNA methylation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 27 Jun 2017 14:03 |
Last Modified: | 10 Nov 2023 12:35 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/cdev.12957 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:118233 |