Smith, Alexandra Gwen orcid.org/0000-0002-1111-966X, Crouch, Simon orcid.org/0000-0002-3026-2859, Lax, Stephanie Joyce orcid.org/0000-0002-7000-9364 et al. (6 more authors) (2015) Lymphoma incidence, survival and prevalence 2004–2014:sub-type analyses from the UK’s Haematological Malignancy Research Network. British journal of cancer. pp. 1575-1584. ISSN 1532-1827
Abstract
Background: Population-based information about cancer occurrence and survival are required to inform clinical practice and research; but for most lymphomas data are lacking. Methods: Set within a socio-demographically representative UK population of nearly 4 million, lymphoma data (N ¼ 5796) are from an established patient cohort. Results: Incidence, survival (overall and relative) and prevalence estimates for 420 subtypes are presented. With few exceptions, males tended to be diagnosed at younger ages and have significantly (Po0.05) higher incidence rates. Differences were greatest at younger ages: the o15 year male/female rate ratio for all subtypes combined being 2.2 (95% CI 1.3–3.4). These gender differences impacted on prevalence; most subtype estimates being significantly (Po0.05) higher in males than females. Outcome varied widely by subtype; survival of patients with nodular lymphocyte predominant Hodgkin lymphoma approached that of the general population, whereas less than a third of those with other B-cell (e.g., mantle cell) or T-cell (e.g., peripheral-T) lymphomas survived for Z5 years. No males/female survival differences were detected. Conclusions: Major strengths of our study include completeness of ascertainment, world-class diagnostics and generalisability. The marked variations demonstrated confirm the requirement for ‘real-world’ data to inform aetiological hypotheses, health-care planning and the future monitoring of therapeutic changes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 Cancer Research UK. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 22 Jun 2017 15:00 |
Last Modified: | 27 Dec 2024 00:07 |
Published Version: | https://doi.org/10.1038/bjc.2015.94 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1038/bjc.2015.94 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117995 |