Ridger, V.C., Boulanger, C.M. orcid.org/0000-0003-4163-669X, Angelillo-Scherrer, A. et al. (16 more authors) (2017) Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thromb Haemost, 117 (7). pp. 1296-1316. ISSN 0340-6245
Abstract
Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as "microparticles". There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Schattauer. This is an author produced version of a paper subsequently published in Thrombosis and Haemostasis. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Atherothrombosis; cell-cell interactions; inflammatory mediators; macrophage |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Jun 2017 09:22 |
Last Modified: | 01 Jun 2018 00:39 |
Published Version: | https://doi.org/10.1160/TH16-12-0943 |
Status: | Published |
Publisher: | Schattauer |
Refereed: | Yes |
Identification Number: | 10.1160/TH16-12-0943 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117711 |