Partridge, B.M. orcid.org/0000-0002-8550-9994, Callingham, M., Lewis, W. et al. (1 more author) (2017) Arylative Intramolecular Allylation of Ketones with 1,3-Enynes Enabled by Catalytic Alkenyl-to-Allyl 1,4-Rh(I) Migration. Angewandte Chemie International Edition, 56 (25). pp. 7227-7232. ISSN 1433-7851
Abstract
Alkenyl-to-allyl 1,4-rhodium(I) migration enablesthe generation of nucleophilic allylrhodium(I) species byremote C-H activation. This new mode of reactivity was employed in the diastereoselective reaction of arylboron reagents with substrates containing a 1,3-enyne tethered toaketone,togive products containing three contiguous stereocenters. The products can be obtained in high enantio-selectivities using achiral sulfur-alkene ligand.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co.KGaA. This is an open access article under the terms of the CreativeCommons AttributionLicense, which permits use, distribution andreproduction in any medium, provided the original work is properlycited. |
Keywords: | allylic compounds; cyclization; isomerization; reaction mechanisms; rhodium |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Jun 2017 11:33 |
Last Modified: | 08 Apr 2019 13:03 |
Published Version: | https://doi.org/10.1002/anie.201703155 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201703155 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117220 |
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