Silva-Fernández, Lucía, Otón, Teresa, Askanase, Anca et al. (24 more authors) (2017) Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature. Reumatología clínica. ISSN 2173-5743
Abstract
Objectives The course and long-term outcome of pure membranous lupus nephritis (MLN) are little understood. The aims of this study are to evaluate the clinical features, course, outcome and prognostic indicators in pure MLN and to determine the impact of ethnicity and the type of health insurance on the course and prognosis of pure MLN. Methods We conducted a retrospective review of medical records of 150 patients with pure MLN from Spain and the USA. Results Mean age was 34.2±12.5 and 80% were women. Sixty-eight percent of patients had nephrotic syndrome at diagnosis. The average serum creatinine was 0.98±0.78mg/dl. Six percent of patients died and 5.3% developed end-stage renal disease (ESRD). ESRD was predicted by male sex, hypertension, dyslipidemia, high basal 24h-proteinuria, high basal serum creatinine and a low basal creatinine clearance. Age, cardiac insufficiency, peripheral artheriopathy, hemodialysis and not having received mycophenolate mofetil or antimalarials for MLN predicted death. Conclusions Pure MLN frequently presents with nephrotic syndrome, high proteinuria and normal serum creatinine. Its prognosis is favourable in maintaining renal function although proteinuria usually persists over time. Baseline cardiovascular disease and not having a health insurance are related with poor prognosis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Keywords: | Systemic lupus erythematosus,Retrospective review,Membranous glomerulonephritis |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 02 Jun 2017 10:15 |
Last Modified: | 16 Oct 2024 13:48 |
Published Version: | https://doi.org/10.1016/j.reuma.2017.04.005 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1016/j.reuma.2017.04.005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117215 |
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