Keijsers, J., Leguy, C., Narracott, A. orcid.org/0000-0002-3068-6192 et al. (3 more authors) (2018) Modelling regulation of vascular tone following muscle contraction: model development, validation and global sensitivity analysis. Journal of Computational Science, 24. pp. 143-159. ISSN 1877-7503
Abstract
In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Journal of Computational Science. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Regulation of vascular tone; Metabolic regulation; Myogenic regulation; Baroreflex; 1D pulse wave propagation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Jun 2017 14:03 |
Last Modified: | 27 Jul 2023 09:24 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jocs.2017.04.007 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117210 |