Griggs, Samuel D., Thompson, Nathan, Tape, Daniel T. et al. (2 more authors) (2017) A Two-Step Synthesis of 2-Spiropiperidines. Chemistry : A European Journal. pp. 9262-9265. ISSN 1521-3765
Abstract
A general two-step synthesis of 2-spiropiperidines has been developed. δ-Amino-β-ketoesters can be reacted with cyclic ketones to generate 2-spiropiperidines in good to excellent yields. The 2-spiropiperidines formed occupy an under-explored region of 3D-chemical space and are novel scaffolds for use in drug discovery programs. These 2-spiropiperidines can be further functionalised to generate small highly sp3-rich structures, which exhibit an excellent likeness to lead-molecules in drug discovery.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Maitland–Japp,medicinal chemistry,piperidine,scaffolds,spirocyclic |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 01 Jun 2017 09:00 |
Last Modified: | 21 Dec 2024 00:12 |
Published Version: | https://doi.org/10.1002/chem.201702467 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201702467 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:117150 |
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Filename: Final_Clarke_2_spiropiperidine.docx
Description: Final Clarke 2-spiropiperidine