Chavali, PL, Stojic, L, Meredith, LW et al. (13 more authors) (2017) Neurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication. Science, 357 (6346). pp. 83-88. ISSN 0036-8075
Abstract
A recent outbreak of Zika virus in Brazil has led to a simultaneous increase in reports of neonatal microcephaly. Zika targets cerebral neural precursors, a cell population essential for cortical development, but the cause of this neurotropism remains obscure. Here we report that the neural RNA-binding protein Musashi-1 (MSI1) interacts with the Zika genome and enables viral replication. Zika infection disrupts the binding of MSI1 to its endogenous targets, thereby deregulating expression of factors implicated in neural stem cell function. We further show that MSI1 is highly expressed in neural progenitors of the human embryonic brain, and is mutated in individuals with autosomal recessive primary microcephaly. Selective MSI1 expression in neural precursors could therefore explain the exceptional vulnerability of these cells to Zika infection.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2017, The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Vol. 357 on 1 June 2017, https://doi.org/10.1126/science.aam9243 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Funding Information: | Funder Grant number Cancer Research UK C24461/A12772 |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 May 2017 09:34 |
Last Modified: | 01 Dec 2017 01:39 |
Status: | Published |
Publisher: | American Association for the Advancement of Science |
Identification Number: | 10.1126/science.aam9243 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:116963 |