Jones, P, Cade, JE orcid.org/0000-0003-3421-0121, Evans, CEL orcid.org/0000-0002-4065-4397 et al. (2 more authors) (2017) The Mediterranean diet and risk of colorectal cancer in the UK women's cohort study. International Journal of Epidemiology, 46 (6). pp. 1786-1796. ISSN 0300-5771
Abstract
Background: Evidence from epidemiological studies investigating associations between adherence to the Mediterranean diet and colorectal cancer is inconsistent. The aim of this study is to assess whether adherence to the Mediterranean dietary pattern is associated with reduced incidence of cancers of the colon and rectum in the UK Women’s Cohort Study. Method: A total of 35 372 women were followed for a median of 17.4 years. A 10-component score indicating adherence to the Mediterranean diet was generated for each cohort participant using a 217-item food frequency questionnaire. The Mediterranean diet score ranged from 0 for minimal adherence to 10 for maximal adherence. Cox proportional hazards regression was used to provide adjusted hazard ratios (HR) and 95% confidence intervals (CI) for colon and rectal cancer risk. Results: A total of 465 incident colorectal cancer cases were documented. In the multivariable-adjusted model, the test for trend was positive (HR=0.88, 95% CI: 0.78 to 0.99; Ptrend = 0.03) for a 2-point increment in the Mediterranean diet score. For rectal cancer, a 2-point increment in the Mediterranean diet score resulted in an HR (95% CI) of 0.69 (0.56 to 0.86) whilst a 62% linear reduced risk (HR 0.38; 95% CI: 0.20 to 0.74; Ptrend < 0.001) was observed for women within the highest vs. the lowest category of the MD score. Estimates for an association with colon cancer were weak (Ptrend = 0.41). Conclusion: Findings suggest women adhering to a Mediterranean dietary pattern may have a lower risk of colorectal cancer, especially rectal cancer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author 2017; Published by Oxford University Press on behalf of the International Epidemiological Association. This is a pre-copyedited, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The version of record, Petra Jones, Janet E Cade, Charlotte E.L. Evans, Neil Hancock, Darren C. Greenwood; The Mediterranean diet and risk of colorectal cancer in the UK Women’s Cohort Study, International Journal of Epidemiology, dyx155, https://doi.org/10.1093/ije/dyx155, is available online at: https://doi.org/10.1093/ije/dyx155. |
Keywords: | Mediterranean diet; epidemiology; colonic neoplasms; rectal neoplasms |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 May 2017 11:10 |
Last Modified: | 19 Aug 2018 00:38 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/ije/dyx155 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:116330 |