Yee, Daniel, Coles, Mark C orcid.org/0000-0001-8079-9358 and Lagos, Dimitris orcid.org/0000-0003-0637-281X (2017) microRNAs in the Lymphatic Endothelium:Master Regulators of Lineage Plasticity and Inflammation. Frontiers in immunology. 104. ISSN 1664-3224
Abstract
microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen trafficking, cytokine secretion, and inducing peripheral tolerance. Here, we review the role of miRNAs in the lymphatic endothelium with a particular focus on their role in lymphatic endothelial cell (LEC) plasticity, inflammation, and regulatory function. We highlight the lineage plasticity of LECs during inflammation and the importance of understanding the regulatory role of miRNAs in these processes. We propose that targeting miRNA expression in lymphatic endothelium can be a novel strategy in treating human pathologies associated with lymphatic dysfunction.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Yee, Coles and Lagos. |
Keywords: | Journal Article,Review |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 08 May 2017 10:40 |
Last Modified: | 21 Jan 2025 17:26 |
Published Version: | https://doi.org/10.3389/fimmu.2017.00104 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3389/fimmu.2017.00104 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:116082 |