Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Abstract

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10−10), 3p22.1 (rs67311347, P=2.5 × 10−8), 3q26.2 (rs10936602, P=8.8 × 10−9), 8p21.3 (rs2241261, P=5.8 × 10−9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10−8), 11q22.3 (rs74911261, P=2.1 × 10−10) and 14q24.2 (rs4903064, P=2.2 × 10−24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

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Item Type:	Article
Authors/Creators:	Scelo, G Purdue, MP Brown, KM Johansson, M Wang, Z Eckel-Passow, JE Ye, Y Hoffman, JN Choi, J Foll, M Gaborieau, V Machiela, MJ Colli, LM Li, P Sampson, JN Abedi-Ardekani, B Besse, C Blanche, H Boland, A Burdette, L Charbrier, A Durand, G Le Calvez-Kelm, F Prokhortchouk, E Robinot, N Skyrabin, KG Wozniak, MB Yeager, M Basta-Jovanovich, G Dzamic, Z Foretova, L Holcatova, I Janout, V Mates, D Mukeriya, A Rascu, S Zaridze, D Bencko, V Cybulski, C Fabianova, E Jinga, V Lissowska, J Lubinski, J Navratilova, M Rudnai, P Szeszenia-Dabrowska, N Benhamou, S Cancel-Tassin, G Cussenot, O Baglietto, L Boeing, H Khaw, K-T Weiderpass, E Ljungberg, B Sitaram, RT Bruinsma, F Jordan, SJ Severi, G Winship, I Hveem, K Vatten, LJ Fletcher, T Koppova, K Larsson, SC Wolk, A Banks, RE https://orcid.org/0000-0002-0042-8715 Selby, PJ Easton, DF Pharoah, P Andreotti, G Beane Freeman, LE Koutros, S Albanes, D Mannisto, S Weinstein, S Clark, PE Edwards, TL Lipworth, L Gapstur, SM Stevens, VL Carol, H Freedman, ML Pomerantz, MM Cho, E Kraft, P Preston, MA Wilson, KM Gaziano, JM Sesso, HD Black, A Freedman, ND Huang, WY Anema, JG Kahnoski, RJ Lane, BR Noyes, SL Petillo, D Teh, BT Peters, U White, E Anderson, GL Johnson, L Luo, J Buring, J Lee, I-M Chow, W-H Moore, LE Wood, C Eisen, T Henrion, M Larkin, J Barman, P Leibovich, BC Choueiri, TK Lathrop, GM Rothman, N Deleuze, J-F McKay, JD Parker, AS Wu, X Houlston, RS Brennan, P Chanock, SJ
Copyright, Publisher and Additional Information:	(c)The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/
Dates:	Accepted: 24 April 2017 Published (online): 9 June 2017 Published: 9 June 2017
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	05 May 2017 14:06
Last Modified:	04 Jul 2017 15:17
Status:	Published
Publisher:	Nature Publishing Group
Identification Number:	10.1038/ncomms15724
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:116006

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Genome-wide association study identifies multiple risk loci for renal cell carcinoma

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