Greener solvents for solid-phase synthesis

Abstract

The use of a variety of green solvents to swell a diverse range of resins used in solid-phase synthesis is investigated. Good swelling is shown to depend on the structure of the resin and the solvent. A modelling approach based on use of a training set of solvents is used to predict which green solvents will, and will not, swell a particular resin. The chemical relevance of the swelling results is confirmed by an experimental study of a solid-supported Ugi reaction carried out in green solvents.

Metadata

Item Type:	Article
Authors/Creators:	Lawrenson, Stefan North, Michael https://orcid.org/0000-0002-6668-5503 Peigneguy, Fanny Routledge, Anne https://orcid.org/0000-0003-4008-7545
Copyright, Publisher and Additional Information:	© The Royal Society of Chemistry 2017
Dates:	Published: 21 February 2017 Published (online): 21 December 2016 Accepted: 20 December 2016
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Chemistry (York)
Depositing User:	Pure (York)
Date Deposited:	28 Apr 2017 13:40
Last Modified:	14 Jan 2025 00:08
Published Version:	https://doi.org/10.1039/c6gc03147a
Status:	Published
Refereed:	Yes
Identification Number:	10.1039/c6gc03147a
Related URLs:	http://www.scopus.com/inward/record.url?...
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:115811

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Greener solvents for solid-phase synthesis

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