Siervo, M, Faber, P, Lara, J et al. (7 more authors) (2015) Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure. Metabolism, 64 (8). pp. 896-904. ISSN 0026-0495
Abstract
Objectives Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different changes in total and resting EE and if (2) they influenced the level of adaptive thermogenesis, defined as the decline in total or resting EE not accounted by changes in body composition. Methods Three groups of six, obese men participated in a total fast for 6 days to achieve a 5% WL and a very low calorie (VLCD, 2.5 MJ/day) for 3 weeks or a low calorie (LCD, 5.2 MJ/day) diet for 6 weeks to achieve a 10% WL. A four-component model was used to measure body composition. Indirect calorimetry was used to measure resting EE. Total EE was measured by doubly labelled water (VLCD, LCD) and 24-hour whole-body calorimetry (fasting). Results VLCD and LCD showed a similar degree of metabolic adaptation for total EE (VLCD = − 6.2%; LCD = − 6.8%). Metabolic adaptation for resting EE was greater in the LCD (− 0.4 MJ/day, − 5.3%) compared to the VLCD (− 0.1 MJ/day, − 1.4%) group. Resting EE did not decrease after short-term fasting and no evidence of adaptive thermogenesis (+ 0.4 MJ/day) was found after 5% WL. The rate of WL was inversely associated with changes in resting EE (n = 30, r = 0.− 42, p = 0.01). Conclusions The rate of WL did not appear to influence the decline in total EE in obese men after 10% WL. Approximately 6% of this decline in total EE was explained by mechanisms of adaptive thermogenesis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, Elsevier Ltd. This is an author produced version of a paper published in Metabolism. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Obesity; Weight loss; Energy expenditure; Metabolic adaptation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Aug 2017 14:23 |
Last Modified: | 31 Aug 2017 14:32 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.metabol.2015.03.011 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:115295 |