Noy, A, Sutthibutpong, T and Harris, SA (2016) Protein/DNA interactions in complex DNA topologies: expect the unexpected. Biophysical Reviews, 8 (S1). pp. 145-155. ISSN 1867-2450
Abstract
DNA supercoiling results in compacted DNA structures that can bring distal sites into close proximity. It also changes the local structure of the DNA, which can in turn influence the way it is recognised by drugs, other nucleic acids and proteins. Here, we discuss how DNA supercoiling and the formation of complex DNA topologies can affect the thermodynamics of DNA recognition. We then speculate on the implications for transcriptional control and the three-dimensional organisation of the genetic material, using examples from our own simulations and from the literature. We introduce and discuss the concept of coupling between the multiple length-scales associated with hierarchical nuclear structural organisation through DNA supercoiling and topology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2016, The Author(s). This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Keywords: | DNA supercoiling; DNA topology; DNA-binding proteins; Computer simulations; Thermodynamics; DNA structural organisation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Theoretical Physics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Apr 2017 14:24 |
Last Modified: | 19 Nov 2018 12:20 |
Published Version: | https://doi.org/10.1007/s12551-016-0241-7 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s12551-016-0241-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:115251 |