Tucker, G.T. (2017) Personalized Drug Dosage – Closing the Loop. Pharmaceutical Research, 34 (8). pp. 1539-1543. ISSN 0724-8741
Abstract
A brief account is given of various approaches to the individualization of drug dosage, including the use of pharmacodynamic markers, therapeutic monitoring of plasma drug concentrations, genotyping, computer-guided dosage using ‘dashboards’, and automatic closed-loop control of pharmacological action. The potential for linking the real patient to his or her ‘virtual twin’ through the application of physiologically-based pharmacokinetic modeling is also discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Keywords: | drug dosage; personalized medicine; pharmacogenetics; physiologically-based pharmacokinetic modeling; therapeutic drug monitoring |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Apr 2017 10:54 |
Last Modified: | 29 Jan 2018 11:48 |
Published Version: | https://doi.org/10.1007/s11095-016-2076-0 |
Status: | Published |
Publisher: | American Association of Pharmaceutical Scientists |
Refereed: | Yes |
Identification Number: | 10.1007/s11095-016-2076-0 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:115137 |