Mackie, AR orcid.org/0000-0002-5681-0593, Goycoolea, FM, Menchicchi, B et al. (10 more authors) (2017) Innovative Methods and Applications in Mucoadhesion Research. Macromolecular Bioscience, 17 (8). 1600534. ISSN 1616-5187
Abstract
The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: [. R. Mackie, F. M. Goycoolea, B. Menchicchi, C. M. Caramella, F. Saporito, S. Lee, K. Stephansen, I. S. Chronakis, M. Hiorth, M. Adamczak, M. Waldner, H. Mørck Nielsen, L. Marcelloni, Macromol. Biosci. 2017, 1600534.], which has been published in final form at http://doi.org/10.1002/mabi.201600534. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | mucoadhesion; mucomimetic materials; mucus; multiscale; pharmaceutical development |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Apr 2017 09:20 |
Last Modified: | 06 Apr 2018 00:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mabi.201600534 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:115054 |