Rayner, Peter J. orcid.org/0000-0002-6577-4117, Burns, Michael J. orcid.org/0000-0002-5569-1270, Olaru, Alexandra M. orcid.org/0000-0002-2244-1048 et al. (6 more authors) (2017) Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Proceedings of the National Academy of Sciences of the United States of America. 2016-20457RR. E3188-E3194. ISSN 1091-6490
Abstract
Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that ordinarily impractical measurements become possible. The potential to revolutionize analytical NMR and clinical diagnosis through this approach reflect this area's most compelling outcomes. Methods to optimize the low cost parahydrogen based approach signal amplification by reversible exchange (SABRE) with studies on a series of biologically relevant nicotinamides and methyl nicotinates are detailed. These procedures involve specific 2H-labelling in both the agent and catalyst and achieve polarization lifetimes of ca. 2 minutes with 50% polarization in the case of 4,6-d2-methylnicotinate. As a 1.5 T hospital scanner has an effective 1H polarization level of just 0.0005% this strategy should result in compressed detection times for chemically discerning measurements that probe disease. To demonstrate this techniques generality, we exemplify further studies on a range of pyridazine, pyrimidine, pyrazine and isonicotinamide analogues that feature as building blocks in biochemistry and many disease treating drugs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Psychology (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z |
Depositing User: | Pure (York) |
Date Deposited: | 05 Apr 2017 09:20 |
Last Modified: | 03 Mar 2025 00:04 |
Published Version: | https://doi.org/10.1073/pnas.1620457114 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1073/pnas.1620457114 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114593 |