Dow, M, Marchetti, F, Abrahams, KA et al. (4 more authors) (2017) Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity. Chemistry - A European Journal, 23 (30). pp. 7207-7211. ISSN 0947-6539
Abstract
A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12-20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the discovery of a series of macrocycles with significant antimycobacterial activity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | antimycobacterials; diversity-oriented synthesis; macrocycles |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Apr 2017 11:08 |
Last Modified: | 05 May 2018 19:12 |
Published Version: | https://doi.org/10.1002/chem.201701150 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/chem.201701150 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114554 |