Alves, D. B. M., Bingle, L. orcid.org/0000-0002-4587-9384, Bingle, C. D. orcid.org/0000-0002-5405-6988 et al. (4 more authors) (2017) BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands. Brazilian oral research, 31. e6. ISSN 1807-3107
Abstract
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Sociedade Brasileira de Pesquisa Odontológica - SBPqO. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/deed.en |
Keywords: | Autoantigens; Epithelium; Fetal Development; Fetus; Gestational Age; Glycoproteins; Head; Humans; Immunohistochemistry; Neck; Palate; Phosphoproteins; Proteins; Retrospective Studies; Salivary Glands; Salivary Proteins and Peptides; Time Factors; Tongue |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Apr 2017 14:34 |
Last Modified: | 07 Jul 2023 15:54 |
Status: | Published |
Publisher: | Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
Refereed: | Yes |
Identification Number: | 10.1590/1807-3107BOR-2017.vol31.0006 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114354 |
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