Camidge, D.R., Randall, K.R., Foster, J.R. et al. (6 more authors) (2005) Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies. British Journal of Cancer, 92 (10). pp. 1837-1841. ISSN 0007-0920
Abstract
We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2005 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
Keywords: | Adolescent; Adult; Antineoplastic Agents; Biomarkers; Cell Cycle; Cell Proliferation; Endpoint Determination; Hair; Humans; Immunohistochemistry; Male; Middle Aged; Reproducibility of Results; Specimen Handling |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Mathematics and Statistics (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 16 May 2017 14:11 |
Last Modified: | 16 May 2017 14:11 |
Published Version: | https://doi.org/10.1038/sj.bjc.6602558 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/sj.bjc.6602558 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114315 |
Download
Licence: CC-BY-NC-SA 3.0