Donald, James Robert orcid.org/0000-0002-2176-4902 and Unsworth, William Paul orcid.org/0000-0002-9169-5156 (2017) Ring expansion reactions in the synthesis of macrocycles and medium-sized rings. Chemistry : A European Journal. pp. 8780-8799. ISSN 1521-3765
Abstract
Functionalised macrocycles and medium-sized rings have applications in a number of scientific fields, ranging from medicinal chemistry and supramolecular chemistry, to catalysis and nanotechnology. However, their value in these areas can be undermined by a simple, but important limitation: large ring systems are very often difficult to make. Traditional end-to-end cyclisation reactions of long linear precursors are typically unpredictable and impractical processes, mainly due to unfavourable enthalpic and entropic factors. Most published methods to make large rings focus on minimising the damage inflicted by performing the difficult cyclisation step; in contrast, ring expansion reactions enable it to be avoided altogether. In this review, we seek to highlight how 'growing' rings from existing cyclic systems via ring expansion can expedite the efficient, practical and scalable synthesis of macrocycles and medium-sized rings.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Journal Article |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Mar 2017 12:00 |
Last Modified: | 21 Jan 2025 17:25 |
Published Version: | https://doi.org/10.1002/chem.201700467 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201700467 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114123 |
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