Guo, Q., Burgess, S., Turman, C. et al. (132 more authors) (2017) Body mass index and breast cancer survival: a Mendelian randomization analysis. International Journal of Epidemiology, 46 (6). pp. 1814-1822. ISSN 0300-5771
Abstract
Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomisation analysis to investigate a possible causal role of BMI in survival from breast cancer.
Methods: We used individual-level data from six large breast cancer case-cohorts including a total of 36,210 individuals (2,475 events) of European ancestry. We created BMI genetic risk score (GRS) based on genotypes at 94 known BMI associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis.
Results: BMI genetic score was found to be associated with reduced breast cancer specific survival for estrogen receptor (ER) - positive cases (HR=1.11, per one-unit increment of GRS, 95% CI 1.01-1.22, P=0.03). We observed no association for ER-negative cases (HR=1.00, per one-unit increment of GRS, 95% CI 0.89-1.13, P=0.95).
Conclusion: Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Body mass index; breast cancer survival; mendelian randomisation; epidemiology; genetics |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Funding Information: | Funder Grant number BREAST CANCER NOW UNSPECIFIED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 29 Mar 2017 15:35 |
Last Modified: | 12 Jan 2018 11:07 |
Published Version: | https://doi.org/10.1093/ije/dyx131 |
Status: | Published |
Publisher: | Oxford University Press |
Refereed: | Yes |
Identification Number: | 10.1093/ije/dyx131 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:114051 |