Blenkinsop, A., Anderson, S. orcid.org/0000-0002-7452-5681 and Gurney, K. (2017) Frequency and function in the basal ganglia: the origins of beta and gamma band activity. Journal of Physiology, 595 (13). pp. 4525-4548. ISSN 0022-3751
Abstract
Neural oscillations in the basal ganglia are well studied yet remain poorly understood. Behavioural correlates of spectral activity are well described, yet a quantitative hypothesis linking time domain dynamics and spectral properties to basal ganglia function has been lacking. We show, for the first time, that a unified description is possible by interpreting previously ignored structure in data describing GPi responses to cortical stimulation. These data were used to expose a pair of distinctive neuronal responses to the stimulation. This observation formed the basis for a new mathematical model of the BG, quantitatively fitted to the data, which describes the dynamics in the data, and is validated against other stimulus protocol experiments. A key new result is that when the model is run using inputs hypothesised to occur during the performance of a motor task, beta and gamma frequency oscillations emerge naturally during static-force and movement respectively, consistent with experimental local field potentials. This new model predicts that the pallido-striatum connection has a key role in the generation of beta band activity, and that the gamma band activity associated with motor task performance has its origins in the pallido-subthalamic feedback loop. The network's functionality as a selection-mechanism also occurs as an emergent property, and closer fits to the data gave better selection properties. The model provides a coherent framework for the study of spectral, temporal and functional analyses of the BG and therefore lays the foundation for an integrated approach to study BG pathologies such as Parkinson's disease in silico.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 WIley. This is an author produced version of a paper subsequently published in Journal of Physiology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Automatic Control and Systems Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Mar 2017 12:02 |
Last Modified: | 05 Jun 2018 00:38 |
Published Version: | https://doi.org/10.1113/JP273760 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1113/JP273760 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113391 |