Liossi, Α, Ntountaniotis, D, Kellici, TF et al. (17 more authors) (2017) Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1859 (6). pp. 1089-1098. ISSN 0005-2736
Abstract
The interactions of irbesartan (IRB) and irbesartan–2-hydroxypropyl-β-cyclodextrin (HP-β-CD) complex with Dipalmitoyl Phosphatidylcholine (DPPC) bilayers have been explored utilizing an array of biophysical techniques ranging from Differential Scanning Calorimetry (DSC), Small angle X-ray Scattering (SAXS), ESI Mass-Spectrometry (ESI-MS) and solid state Nuclear Magnetic Resonance (ssNMR). Molecular Dynamics (MD) calculations have been also conducted to complement the experimental results. Irbesartan was found to be embedded in the lipid membrane core and to affect the phase transition properties of the DPPC bilayers. SAXS studies revealed that irbesartan alone does not display perfect solvation since some coexisting irbesartan crystallites are present. In its complexed form IRB gets fully solvated in the membranes showing that encapsulation of IRB in HP-β-CD may have beneficial effects in the ADME properties of this drug. MD experiments revealed the topological and orientational integration of irbesartan into the phospholipid bilayer being placed at about 1 nm from the membrane centre.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier B.V. This is an author produced version of a paper published in Biochimica et Biophysica Acta (BBA) - Biomembranes. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Irbesartan; DPPC; HP-β-CD; Molecular Dynamics; Small Angle X-ray Scattering |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Mar 2017 09:11 |
Last Modified: | 06 Mar 2018 01:38 |
Published Version: | https://doi.org/10.1016/j.bbamem.2017.03.003 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bbamem.2017.03.003 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113387 |