Sormaz, Mladen, Jefferies, Elizabeth orcid.org/0000-0002-3826-4330, Bernhardt, Boris C et al. (6 more authors) (2017) Knowing what from where:Hippocampal connectivity with temporoparietal cortex at rest is linked to individual differences in semantic and topographic memory. Neuroimage. pp. 400-410. ISSN 1053-8119
Abstract
The hippocampus contributes to episodic, spatial and semantic aspects of memory, yet individual differences within and between these functions are not well-understood. In 136 healthy individuals, we investigated whether these differences reflect variation in the strength of connections between functionally-specialised segments of the hippocampus and diverse cortical regions that participate in different aspects of memory. Better topographical memory was associated with stronger connectivity between lingual gyrus and left anterior, rather than posterior, hippocampus. Better semantic memory was associated with increased connectivity between the cuneus/precuneus and left, rather than right, posterior hippocampus. Notably, we observed a double dissociation between semantic and topographical memory: better semantic memory was associated with stronger connectivity between left temporoparietal cortex and left anterior hippocampus, while better topographic memory was linked to stronger connectivity with right anterior hippocampus. Together these data support a division-of-labour account of hippocampal functioning: at the population level, differences in connectivity across the hippocampus reflect functional specialisation for different facets of memory, while variation in these connectivity patterns across individuals is associated with differences in the capacity to retrieve different types of information. In particular, within-hemisphere connectivity between hippocampus and left temporoparietal cortex supports conceptual processing at the expense of spatial ability.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017, Elsevier Inc. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Keywords: | Journal Article,Resting state,Episodic,Large scale dataset,Topographic,Semantic,Hippocampus,Hippocampus/physiology,Parietal Lobe/physiology,Humans,Memory, Episodic,Male,Temporal Lobe/physiology,Young Adult,Magnetic Resonance Imaging,Semantics,Memory/physiology,Neural Pathways/physiology,Brain Mapping,Individuality,Adult,Female |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) The University of York > Faculty of Sciences (York) > Psychology (York) > York Neuroimaging Centre |
Depositing User: | Pure (York) |
Date Deposited: | 07 Mar 2017 11:00 |
Last Modified: | 31 Mar 2025 23:06 |
Published Version: | https://doi.org/10.1016/j.neuroimage.2017.02.071 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.neuroimage.2017.02.071 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113291 |
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