Holen, I, Speirs, V orcid.org/0000-0002-0602-4666, Morrissey, B orcid.org/0000-0003-2369-276X et al. (1 more author) (2017) In vivo models in breast cancer research: progress, challenges and future directions. Disease Models and Mechanisms, 10 (4). pp. 359-371. ISSN 1754-8403
Abstract
Research using animal model systems has been instrumental in delivering improved therapies for breast cancer, as well as in generating new insights into the mechanisms that underpin development of the disease. A large number of different models are now available, reflecting different types and stages of the disease; choosing which one to use depends on the specific research question (s) to be investigated. Based on presentations and discussions from leading experts who attended a recent workshop focused on in vivo models of breast cancer, this article provides a perspective on the many varied uses of these models in breast cancer research, their strengths, associated challenges and future directions. Among the questions discussed were: how well do models represent the different stages of human disease; how can we model the involvement of the human immune system and microenvironment in breast cancer; what are the appropriate models of metastatic disease; can we use models to carry out preclinical drug trials and identify pathways responsible for drug resistance; and what are the limitations of patient-derived xenograft models? We briefly outline the areas where the existing breast cancer models require improvement in light of the increased understanding of the disease process, reflecting the drive towards more personalised therapies and identification of mechanisms of drug resistance.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
Keywords: | Breast cancer, Mouse models, GEMM, PDX, CDX, |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Medicine & Health Faculty Office (Leeds) > Faculty Office Functions (FOMH) (Leeds) > Dean's Office (FOMH) (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Pathology & Tumour Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Mar 2017 10:58 |
Last Modified: | 23 Jun 2023 22:25 |
Published Version: | https://doi.org/10.1242/dmm.028274 |
Status: | Published |
Publisher: | Company of Biologists |
Identification Number: | 10.1242/dmm.028274 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113289 |