Egner, W. orcid.org/0000-0002-2654-9881, Helbert, M., Sargur, R. et al. (6 more authors) (2017) Chlorhexidine Allergy in 4 Specialist Allergy Centres in the UK, 2009-2013: Clinical Features and Diagnostic Tests. Clinical And Experimental Immunology, 188 (3). pp. 380-386. ISSN 0009-9104
Abstract
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the UK following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and sIgE testing were the most common tests used for diagnosis. Fifty-three % of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50-86%), 50% (10-90%) and 35% (17-55%) respectively. Seven percent were negative on screening tests initially, and 12 cases were only positive for a single test despite multiple testing. Intradermal tests appeared most sensitive in this context. Additional sensitisation to other substances used perioperatively, particularly neuromuscular blocking agents (NMBA), was found in 28 patients, emphasising the need to test for possible allergy to all drugs to which the patient was exposed even where chlorhexidine is positive. This article is protected by copyright. All rights reserved.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Wiley. This is an author produced version of a paper subsequently published in Clinical and Experimental Immunology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Anaesthesia; Anaphylaxis; Chlorhexidine Allergy; Skin Tests; Specific IgE |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Mar 2017 15:05 |
Last Modified: | 07 Jul 2023 15:31 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/cei.12944 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:113243 |