Liu, WJ, Ma, CY, Liu, JJ et al. (2 more authors) (2017) Continuous reactive crystallization of pharmaceuticals using impinging jet mixers. AIChE Journal, 63 (3). pp. 967-974. ISSN 0001-1541
Abstract
For reactive crystallization of pharmaceuticals that show a rapid reaction rate, low solubility of active pharmaceutical ingredient and hence a large supersaturation, it was found in a recent study that a process design which integrates an impinging jet mixer and batch stirred tank produces high quality crystals. The current investigation examines if the short processing time of reactive crystallization permits the impinging jet mixer—stirred tank design to be modified to operate in a continuous mode. The new design combines an impinging jet mixer for feed introduction and reaction with a continuous stirred tank reactor (CSTR) and tubular reactor for crystal growth. A study of reactive crystallization of sodium cefuroxime (an antibiotic), using first a 1L CSTR then scaling to a 50L CSTR, found that the new design produces crystals of higher crystallinity, narrower particle size, and improved product stability, than batch crystallizers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 American Institute of Chemical Engineers. This is the peer reviewed version of the following article: Liu, W. J., Ma, C. Y., Liu, J. J., Zhang, Y. and Wang, X. Z. (2017), Continuous reactive crystallization of pharmaceuticals using impinging jet mixers. AIChE J., 63: 967–974. doi: 10.1002/aic.15438, which has been published in final form at https://doi.org/10.1002/aic.15438. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | reactive crystallization; continuous crystallization; continuous processing of pharmaceuticals; impinging jet mixer; process analytical technology; sodium cefuroxime |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Feb 2017 10:17 |
Last Modified: | 02 Aug 2017 19:38 |
Published Version: | https://doi.org/10.1002/aic.15438 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/aic.15438 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112944 |