Howell, Debra orcid.org/0000-0002-7521-7402, Smith, Alexandra orcid.org/0000-0002-1111-966X, Appleton, Simon et al. (5 more authors) (2017) Multiple myeloma:routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study. British Journal of Haematology. pp. 67-71. ISSN 0007-1048
Abstract
Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ 2 = 13·8, P = 0·0002).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. |
Keywords: | Journal Article,multiple myeloma,emergency presentation,route to diagnosis,survival,clinical characteristics,Outcome Assessment (Health Care),Humans,Middle Aged,Male,Multiple Myeloma/diagnosis,United Kingdom/epidemiology,Phenotype,Aged, 80 and over,Female,Aged,Disease Management,Population Surveillance |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 27 Feb 2017 12:20 |
Last Modified: | 27 Dec 2024 00:09 |
Published Version: | https://doi.org/10.1111/bjh.14513 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1111/bjh.14513 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112910 |
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