Noy, Agnes orcid.org/0000-0003-0673-8949, Maxwell, Anthony and Harris, Sarah A. (2017) Interference between Triplex and Protein Binding to Distal Sites on Supercoiled DNA. Biophysical Journal. pp. 523-531. ISSN 0006-3495
Abstract
have explored the interdependence of the binding of a DNA triplex and a repressor protein to distal recognition sites on supercoiled DNA minicircles using MD simulations. We observe that the interaction between the two ligands through their influence on their DNA template is determined by a subtle interplay of DNA mechanics and electrostatics, that the changes in flexibility induced by ligand binding play an important role and that supercoiling can instigate additional ligand-DNA contacts that would not be possible in simple linear DNA sequences.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Feb 2017 10:20 |
Last Modified: | 22 Jan 2025 00:08 |
Status: | Published |
Refereed: | Yes |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112792 |
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Description: PIIS0006349516343405(1)