Schlesinger, S, Aleksandrova, K, Abar, L et al. (8 more authors) (2017) Adult weight gain and colorectal adenomas – a systematic review and meta-analysis. Annals of Oncology, 28 (6). pp. 1217-1229. ISSN 0923-7534
Abstract
Background: Colorectal adenomas are known as precursors for the majority of colorectal carcinomas. While weight gain during adulthood has been identified as a risk factor for colorectal cancer, the association is less clear for colorectal adenomas. We conducted a systematic review and meta-analysis to quantify the evidence on this association. Methods: We searched MEDLINE up to September 2016 to identify observational (prospective, cross-sectional and retrospective) studies on weight gain during adulthood and colorectal adenoma occurrence and recurrence. We conducted meta-analysis on high weight gain versus stable weight, linear and non-linear dose-response meta-analyses to analyze the association. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using a random effects model. Results: For colorectal adenoma occurrence, the summary OR was 1.39 (95% CI: 1.17-1.65; I2 :43%, N =9 studies, cases=5,507) comparing high (midpoint: 17.4 kg) versus stable weight gain during adulthood and with each 5 kg weight gain the odds increased by 7% (2%-11%; I2 :65%, N=7 studies). Although there was indication of non-linearity (Pnon-linearity <0.001) there was an increased odds of colorectal adenoma throughout the whole range of weight gain. Three studies were identified investigating the association between weight gain and colorectal adenoma recurrence and data were limited to draw firm conclusions. Conclusions: Even a small amount of adult weight gain was related to a higher odds of colorectal adenoma occurrence. Our findings add to the benefits of weight control in adulthood regarding colorectal adenomas occurrence, which might be relevant for early prevention of colorectal cancer.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. This is a pre-copyedited, author-produced PDF of an article accepted for publication in the Annals of Oncology following peer review. The version of record, 'Schlesinger, S, Aleksandrova, K, Abar, L et al (2017) Adult weight gain and colorectal adenomas – a systematic review and meta-analysis. Annals of Oncology. mdx080,' is available online at: https://doi.org/10.1093/annonc/mdx080 |
Keywords: | Body weight gain; body weight change; colorectal adenomas; polyps; meta-analysis; observational studies |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Feb 2017 10:21 |
Last Modified: | 06 Mar 2018 01:38 |
Published Version: | https://doi.org/10.1093/annonc/mdx080 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/annonc/mdx080 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112636 |