Egner, W, Helbert, M, Sargur, R et al. (6 more authors) (2017) Chlorhexidine allergy in four specialist allergy centres in the United Kingdom, 2009–13: clinical features and diagnostic tests. Clinical and Experimental Immunology, 188 (3). pp. 380-386. ISSN 0009-9104
Abstract
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the United Kingdom following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life‐threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and specific immunoglobulin (sIg)E testing were the most common tests used for diagnosis. Fifty‐three per cent of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50–86%), 50% (10–90%) and 35% (17–55%), respectively. Seven per cent were negative on screening tests initially, and 12 cases were only positive for a single test despite multiple testing. Intradermal tests appeared most sensitive in this context. Additional sensitization to other substances used perioperatively, particularly neuromuscular blocking agents (NMBA), was found in 28 patients, emphasizing the need to test for possible allergy to all drugs to which the patient was exposed even where chlorhexidine is positive.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 British Society for Immunology. This is the peer reviewed version of the following article: Egner, W. , Helbert, M. , Sargur, R. , Swallow, K. , Harper, N. , Garcez, T. , Savic, S. , Savic, L. and Eren, E. (2017), Chlorhexidine allergy in four specialist allergy centres in the United Kingdom, 2009–13: clinical features and diagnostic tests. Clin Exp Immunol, 188: 380-386. doi:10.1111/cei.12944, which has been published in final form at https://doi.org/10.1111/cei.12944. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Anaesthesia; Anaphylaxis; Chlorhexidine Allergy; Skin Tests; Specific IgE |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Feb 2017 11:12 |
Last Modified: | 05 Jul 2018 04:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/cei.12944 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112492 |