McCarthy, NLC, Brooks, NJ, Tyler, AII orcid.org/0000-0003-2116-1084 et al. (4 more authors) (2017) A combined X-ray scattering and simulation study of halothane in membranes at raised pressures. Chemical Physics Letters, 671. pp. 21-27. ISSN 0009-2614
Abstract
Using a combination of high pressure wide angle X-ray scattering experiments and molecular dynamics simulations, we probe the effect of the archetypal general anaesthetic halothane on the lipid hydrocarbon chain packing and ordering in model bilayers and the variation in these parameters with pressure. Incorporation of halothane into the membrane causes an expansion of the lipid hydrocarbon chain packing at all pressures. The effect of halothane incorporation on the hydrocarbon chain order parameter is significantly reduced at elevated pressure.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | X-ray scattering; Molecular dynamics simulations; Halothane; DMPC; General anaesthetics; Pressure reversal |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Feb 2017 10:41 |
Last Modified: | 05 Oct 2017 16:34 |
Published Version: | https://doi.org/10.1016/j.cplett.2016.12.041 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cplett.2016.12.041 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112480 |