Marshall, H., Horsley, A., Taylor, C. et al. (13 more authors) (2017) Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI. Thorax, 72. pp. 760-762. ISSN 0040-6376
Abstract
Hyperpolarised 3He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © BMJ Publishing Group, 2017. This is an author produced version of a paper subsequently published in Thorax. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 CYSTIC FIBROSIS TRUST PJ 555 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 Feb 2017 14:11 |
Last Modified: | 16 Aug 2017 04:58 |
Published Version: | https://doi.org/10.1136/thoraxjnl-2016-208948 |
Status: | Published |
Publisher: | BMJ Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1136/thoraxjnl-2016-208948 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:112445 |