Hiles, M, Culpan, A-M orcid.org/0000-0001-8592-2597, Watts, C et al. (2 more authors) (2017) Neonatal respiratory distress syndrome: Chest X-ray or lung ultrasound? A systematic review. Ultrasound. ISSN 1742-271X
Abstract
Background and aim: Neonatal respiratory distress syndrome (NRDS) is a leading cause of morbidity in preterm new-born babies (< 37 weeks gestation age [GA]). The current diagnostic reference standard includes clinical testing and chest radiography (CXR) with associated exposure to ionising radiation. The aim of this review was to compare the diagnostic accuracy of lung ultrasound (LUS) against the reference standard in symptomatic neonates of ≤ 42 weeks GA. Methods: A systematic search of literature published between 1990 and 2016 identified 803 potentially relevant studies. Six studies met the review inclusion criteria and were retrieved for analysis. Quality assessment was performed before data extraction and meta-analysis. Results: Four prospective cohort studies and two case control studies included 480 neonates. All studies were of moderate methodological quality although heterogeneity was evident across the studies. The pooled sensitivity and specificity of LUS were 97% (95% confidence interval [CI] 94%-99%) and 91% (CI: 86%-95%) respectively. False positive diagnoses were made in sixteen cases due to pneumonia (n=8), transient tachypnoea (n=3), pneumothorax (n=1) and meconium aspiration syndrome (n=1); the diagnoses of the remaining three false positive results were not specified. False negatives diagnoses occurred in nine cases, only two were specified as air-leak syndromes. Conclusions: LUS was highly sensitive for the detection of NRDS although there is potential to miss co-morbid air-leak syndromes (ALS). Further research into LUS diagnostic accuracy for neonatal ALS and economic modelling for service integration is required before LUS can replace CXR as the imaging component of the reference standard.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2017. This is an author produced version of a paper published in Ultrasound. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Neonatal respiratory distress syndrome; lung ultrasound; chest X-ray; diagnosis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Division of Biomedical Imaging (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Feb 2017 11:02 |
Last Modified: | 16 Jan 2018 02:06 |
Published Version: | https://doi.org/10.1177/1742271X16689374 |
Status: | Published |
Publisher: | SAGE Publications |
Identification Number: | 10.1177/1742271X16689374 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:111907 |