Hugentobler, KG, Rasparini, M, Thompson, LA orcid.org/0000-0003-1128-7927 et al. (3 more authors) (2017) Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor. Organic Process Research and Development, 21 (2). pp. 195-199. ISSN 1083-6160
Abstract
In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research and Development, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.oprd.6b00346. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | batch reactor; enzyme catalysis; flow chemistry; Thermomyces lanuginosus lipase; ticagrelor |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Feb 2017 10:53 |
Last Modified: | 22 Dec 2017 01:38 |
Published Version: | https://doi.org/10.1021/acs.oprd.6b00346 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.oprd.6b00346 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:111506 |