Kwok, M, Rawstron, AC, Varghese, A et al. (6 more authors) (2016) Minimal residual disease is an independent predictor for 10-year survival in CLL. Blood, 128 (24). pp. 2770-2773. ISSN 0006-4971
Abstract
Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to independently predict for clinical outcome in patients receiving combination chemoimmunotherapy in the frontline setting. However, the long-term prognostic value of MRD status in other therapeutic settings remains unclear. Here, we retrospectively analyzed, with up to 18 years follow-up, all patients at our institution who achieved at least a partial response (PR) with various therapies between 1996 and 2007, and received a bone marrow MRD assessment at the end of treatment according to the international harmonized approach. MRD negativity correlated with both progression-free survival (PFS) and overall survival (OS) independent of the type and line of treatment, as well as known prognostic factors including adverse cytogenetics. The greatest impact of achieving MRD negativity was seen in patients receiving frontline treatment, with 10-year PFS of 65% vs 10% and 10-year OS of 70% vs 30% for MRD-negative vs MRD-positive patients, respectively. Our results demonstrate the long-term benefit of achieving MRD negativity, regardless of the therapeutic setting and treatment modality, and support its use as a prognostic marker for long-term PFS and as a potential therapeutic goal in CLL.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This research was originally published in Blood. Kwok, et al., Minimal residual disease is an independent predictor for 10-year survival in CLL. 2016, 128 (24): pp2770-pp2773. © 2016 by The American Society of Hematology. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Experimental Haematology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Jan 2017 12:39 |
Last Modified: | 03 Oct 2017 07:20 |
Published Version: | https://doi.org/10.1182/blood-2016-05-714162 |
Status: | Published |
Publisher: | American Society of Hematology |
Identification Number: | 10.1182/blood-2016-05-714162 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:111386 |