Haynes, BI, Bunce, D, Kochan, NA et al. (3 more authors) (2017) Associations between reaction time measures and white matter hyperintensities in very old age. Neuropsychologia, 96. pp. 249-255. ISSN 0028-3932
Abstract
In old age, a relationship has been reported between intraindividual variability (IIV) in reaction time and white matter integrity as evidenced by white matter hyperintensities (WMH). However, it is unclear how far such associations are due to incipient neurodegenerative pathology in the samples investigated. The present study examined the relationship between IIV and WMH in older individuals (N=526) drawn from the Sydney Memory and Ageing Study. Using a complex reaction time (RT) task, greater IIV and mean-RT were related to a higher WMH burden in the frontal lobe. Critically, significant associations remained having taken future dementia into account suggesting that they were not explained by incipient dementia. Additionally, independent measures of executive function accounted for the association between RT metrics and WHM. The results are consistent with the view that frontally-supported cognitive processes are involved in IIV-WMH relations, and that RT measures are sensitive to compromise in white matter structures in non-demented older individuals.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Published by Elsevier Ltd. This is an author produced version of a paper published in Neuropsychologia. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | cognition; executive function; intraindividual variability; reaction time; white matter hyperintensities |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Jan 2017 11:14 |
Last Modified: | 21 Jan 2018 01:38 |
Published Version: | https://doi.org/10.1016/j.neuropsychologia.2017.01... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.neuropsychologia.2017.01.021 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:111276 |