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© 2015 Elsevier. This is an author produced version of a paper subsequently published in Seminars in Cancer Biology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/)

• Accepted: 14 September 2015
• Published (online): 18 November 2015
• Published: December 2015

• Author