Roy, Soumya S. orcid.org/0000-0002-9193-9712, Norcott, Philip orcid.org/0000-0003-4082-2079, Rayner, Peter J. orcid.org/0000-0002-6577-4117 et al. (2 more authors) (2016) A Hyperpolarizable 1H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage. Angewandte Chemie International Edition. pp. 15642-15645. ISSN 1433-7851
Abstract
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are two extremely important techniques with applications ranging from molecular structure determination to human imaging. However, in many cases the applicability of NMR and MRI are limited by inherently poor sensitivity and insufficient nuclear spin lifetime. Here we demonstrate a cost-efficient and fast technique that tackles both issues simultaneously. We use the signal amplification by reversible exchange (SABRE) technique to hyperpolarize the target1H nuclei and store this polarization in long-lived singlet (LLS) form after suitable radiofrequency (rf) pulses. Compared to the normal scenario, we achieve three orders of signal enhancement and one order of lifetime extension, leading to1H NMR signal detection 15 minutes after the creation of the detected states. The creation of such hyperpolarized long-lived polarization reflects an important step forward in the pipeline to see such agents used as clinical probes of disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. |
Keywords: | hyperpolarization,long-lived singlet states,NMR spectroscopy,para-hydrogen,structure elucidation |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Psychology (York) > York Neuroimaging Centre The University of York > Faculty of Sciences (York) > Psychology (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z |
Depositing User: | Pure (York) |
Date Deposited: | 13 Jan 2017 14:19 |
Last Modified: | 26 Nov 2024 00:32 |
Published Version: | https://doi.org/10.1002/anie.201609186 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201609186 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:110580 |
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