Heymann, M.F. and Heymann, D. orcid.org/0000-0001-7777-0669 (2017) Immune environment and osteosarcoma. In: Honoki, K. and Weiss, K.R., (eds.) Osteosarcoma: Biology, behaviour and mechanisms. IntechOpen , pp. 105-120. ISBN 978-953-51-3096-3
Abstract
Immune niche with its huge cell diversity including more specifically tumour infiltrating lymphocytes (TILs), tumour-associated macrophages (TAMs) regulate osteosarcoma (OS) microenvironment. TAMs exert differential activities in the tumour development according to their polarisation. Indeed, in oncology, M1-polarised macrophages are considered as anti-tumour effectors, and M2-polarised macrophages are defined as pro-tumour modulators by increasing the neoangiogenic process. TAM density is correlated with tumour cell proliferation, invasion, metastasis and poor prognosis in various epithelial and haematological cancers and in bone metastasis. Similarly, tumour infiltrating lymphocytes play a key role in tumour development by inducing a local tolerant environment favourable for the tumour growth. The present chapter will describe the main roles of the immune system in the pathogenesis of osteosarcoma and the most recent therapeutic development based on its regulation.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Osteoimmunology; osteosarcoma; macrophage; lymphocyte; microenvironment |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Mar 2017 15:54 |
Last Modified: | 18 Oct 2018 13:21 |
Published Version: | https://doi.org/10.5772/67448 |
Status: | Published |
Publisher: | IntechOpen |
Refereed: | Yes |
Identification Number: | 10.5772/67448 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:110445 |