Takase-Minegishi, K, Horita, N, Kobayashi, K et al. (7 more authors) (2018) Diagnostic test accuracy of ultrasonography for synovitis in rheumatoid arthritis: systematic review and meta-analysis. Rheumatology, 57 (1). pp. 49-58. ISSN 1462-0324
Abstract
Objective. To evaluate diagnostic test accuracy of US compared with MRI for the detection of synovitis in RA patients. Methods. A systematic literature search was performed in the PubMed, EMBASE, Cochrane Library and Web of Science Core Collection databases. Studies evaluating the diagnostic test accuracy of US for synovitis detected by MRI as the reference standard for wrist, MCP, PIP and knee joints were included. To assess the overall accuracy, we calculated the diagnostic odds ratio using a DerSimonian–Laird random effects model and the area under the curve (AUC) for the hierarchical summary receiver operating characteristics using Holling’s proportional hazards models. The summary estimate of the sensitivity and specificity were obtained using the bivariate model. Results. Fourteen of 601 identified articles were included in the review. The diagnostic odds ratio was 11.6 (95% CI 5.6, 24; I2 = 0%), 28 (95% CI 12, 66; I2 = 11%), 23 (95% CI 6.5, 84; I2 = 19%) and 5.3 (95% CI 0.60, 48; I2 = 0%) and the AUC was 0.81, 0.91, 0.91 and 0.61 for wrist, MCP, PIP and knee joints, respectively. The summary estimates of sensitivity and specificity were 0.73 (95% CI 0.51, 0.87)/0.78 (95% CI 0.46, 0.94), 0.64 (95% CI 0.43, 0.81)/0.93 (95% CI 0.88, 0.97), 0.71 (95% CI 0.33, 0.93)/0.94 (95% CI 0.89, 0.97) and 0.91 (95% CI 0.56, 0.99)/0.60 (95% CI 0.20, 0.90) for wrist, MCP, PIP and knee joints, respectively. Conclusion. US is a valid and reproducible technique for detecting synovitis in the wrist and finger joints. It may be considered for routine use as part of the standard diagnostic tools in RA.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) The Author, 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The version of record, "Takase-Minegishi, K, Horita, N, Kobayashi, K et al (2018). Diagnostic test accuracy of ultrasonography for synovitis in rheumatoid arthritis: systematic review and meta-analysis. Rheumatology, 57 (1). pp. 49-58," is available online at: https://doi.org/10.1093/rheumatology/kex036 |
Keywords: | rheumatoid arthritis, ultrasound, magnetic resonance imaging |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Jan 2017 16:32 |
Last Modified: | 03 Mar 2018 01:38 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Identification Number: | 10.1093/rheumatology/kex036 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:110298 |