Silvertown, JD, Wong, BPY, Sivagurunathan, KS et al. (3 more authors) (2017) Remineralization of natural early caries lesions in vitro by P₁₁-4 monitored with photothermal radiometry and luminescence. Journal of Investigative and Clinical Dentistry, 8 (4). e12257. ISSN 2041-1618
Abstract
Aim: The efficacy of self-assembling peptide P11 -4 to regenerate enamel in natural early caries lesions was evaluated over 50 days by photothermal radiometry and luminescence using The Canary System (CS) and The Canary Lab (CL). Methods: Baseline readings for sound and carious sites on smooth surfaces of extracted teeth were obtained by scanning with CS and CL. Teeth were then randomly assigned to a treatment group (TG, treated with P11 -4), a placebo group (PG, same vehicle as treatment group without P11 -4), or a control group (CG, no treatment). All the teeth were then placed in artificial saliva to facilitate natural remineralization, and the sites were rescanned with CS and CL at 7, 14, 30, and 50 days. Results: For carious sites in TG, mean canary numbers (CN) derived from CS decreased significantly (P<.01) from 44±3.8 at baseline to 24±4.9 at day 50; the mean CN for the TG derived from CL also decreased significantly (P<.05), from 65 at baseline to 45 at day 50. In contrast, no significant changes in CN were observed for carious sites in the CG or PG using either CS or CL. Conclusions: P11 -4 promoted the regeneration of early caries.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 John Wiley & Sons Australia, Ltd. This is the peer reviewed version of the following article: Silvertown, JD, Wong, BPY, Sivagurunathan, KS et al. (2017) Remineralization of natural early caries lesions in vitro by P₁₁-4 monitored with photothermal radiometry and luminescence. Journal of Investigative and Clinical Dentistry. ISSN 2041-1618; which has been published in final form at https://doi.org/10.1111/jicd.12257. This article may be used for non-commercial purposes in accordance with the Wiley Terms and Conditions for Self-Archiving. |
Keywords: | Curodont Repair; natural caries; remineralization; self-assembling peptide; The Canary System |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Jan 2017 12:49 |
Last Modified: | 11 Jan 2018 11:36 |
Published Version: | https://doi.org/10.1111/jicd.12257 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/jicd.12257 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:110216 |