Vallée, MR, Schombs, MW, Balaban, ZJ et al. (2 more authors) (2016) Ready display of antigenic peptides in a protein 'mimogen'. Chemical Communications, 52 (14). pp. 3014-3017. ISSN 1359-7345
Abstract
Given the dependence of much modern biology upon the use of antibodies as tools and reagents, their variability and the often associated lack-of-detail about function and identity creates experimental errors. Here we describe the proof-of-principle for a potentially general, versatile method for the display of antigens in a soluble yet standard format on a lateral protein scaffold that mimics normal epitopes in a protein antigen (a 'mimogen') and confirm their utility in phosphorylation-dependent recognition by specific antibodies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Antigens; Peptides |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Dec 2016 13:04 |
Last Modified: | 21 Dec 2016 13:04 |
Published Version: | https://doi.org/10.1039/c5cc08892e |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c5cc08892e |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:109814 |