Liddon, John Timothy Ruskin orcid.org/0000-0002-5287-9817, Clarke, Aimee K, Taylor, Richard J K orcid.org/0000-0002-5880-2490 et al. (1 more author) (2016) Preparation and Reactions of Indoleninyl Halides:Scaffolds for the Synthesis of Spirocyclic Indole Derivatives. Organic Letters. pp. 6328-6331. ISSN 1523-7052
Abstract
The dearomatization of 2-haloindole precursors allows access to indoleninyl halides, a hitherto underexploited functional handle with broad synthetic utility. Indoleninyl iodides have been shown to react via three distinct modes: hydrolysis, nucleophilic substitution, and cross-coupling. This allows a broad array of functionalized spirocyclic indole derivatives to be generated from a common starting material. They are also useful precursors to functionalized quinolines following migratory rearrangement and subsequent derivatization reactions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 20 Dec 2016 11:13 |
Last Modified: | 21 Jan 2025 17:24 |
Published Version: | https://doi.org/10.1021/acs.orglett.6b03221 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.orglett.6b03221 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:109748 |
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