Abernethy, J, Guy, R, Sheridan, EA et al. (5 more authors) (2017) Epidemiology of Escherichia coli bacteraemia in England: results of an enhanced sentinel surveillance programme. Journal of Hospital Infection, 95 (4). pp. 365-375. ISSN 0195-6701
Abstract
Background: Escherichia coli causes over one third of the bacteraemia cases in England each year, and the incidence of these infections is increasing. Aim: To determine the underlying risk factors associated with E. coli bacteraemia. Methods: A three month enhanced sentinel surveillance study involving 35 National Health Service hospitals was undertaken in the winter of 2012/13 to collect risk factor information and further details on the underlying source of infection to augment data already collected by the English national surveillance programme. Antimicrobial susceptibility results for E. coli isolated from blood and urine were also collected. Findings: A total of 1,731 cases of E. coli bacteraemia were included. The urogenital tract was the most commonly reported source of infection (51.2% of cases) with prior treatment for a urinary tract infection being the largest independent effect associated with this infection source. Half of all patients had prior healthcare exposure in the month prior to the bacteraemia with antimicrobial therapy and urinary catheterisation being reported in one third and one fifth of these patients. Prior healthcare exposure was associated with a higher proportion of antibiotic non-susceptibility in the blood culture isolates (P=0.001). Conclusion: Analysis of risk factors suggests potential community and hospital-related interventions particularly better use of urinary catheters and improved antibiotic management of urinary tract infections. As part of the latter strategy, antibiotic resistance profiles need to be closely monitored to ensure treatment guidelines are up to date to limit inappropriate empiric therapy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an author produced version of a paper published in Journal of Hospital Infection. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Urinary Tract Infection, Risk Factors, Healthcare Associated, Community |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Dec 2016 15:07 |
Last Modified: | 16 Dec 2017 01:38 |
Published Version: | https://doi.org/10.1016/j.jhin.2016.12.008 |
Status: | Published |
Publisher: | WB Saunders |
Identification Number: | 10.1016/j.jhin.2016.12.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:109639 |