Genome-wide association study identifies multiple susceptibility loci for glioma

Abstract

Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10−8), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10−11), 12q21.2 (rs12230172, P=7.53 × 10−11) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10−9). Our findings provide further insights into the genetic basis of the different glioma subtypes.

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Item Type:	Article
Authors/Creators:	Kinnersley, B Labussière, M Holroyd, A Di Stefano, A-L Broderick, P Vijayakrishnan, J Mokhtari, K Delattre, J-Y Gousias, K Schramm, J Schoemaker, MJ Fleming, SJ https://orcid.org/0000-0002-7655-4806 Herms, S Heilmann, S Schreiber, S Wichmann, H-E Nöthen, MM Swerdlow, A Lathrop, M Simon, M Bondy, M Sanson, M Houlston, RS
Copyright, Publisher and Additional Information:	(c) 2015, Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Dates:	Published: 1 October 2015 Published (online): 1 October 2015 Accepted: 4 September 2015
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	10 Feb 2017 15:09
Last Modified:	10 Feb 2017 15:09
Published Version:	https://doi.org/10.1038/ncomms9559
Status:	Published
Publisher:	Nature Publishing Group
Identification Number:	10.1038/ncomms9559
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:109630

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Genome-wide association study identifies multiple susceptibility loci for glioma

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