Sethugavalar, B, Teo, MT, Buchan, C et al. (4 more authors) (2016) Impact of prophylactic gastrostomy or reactive NG tube upon patient-reported long term swallow function following chemoradiotherapy for oropharyngeal carcinoma: A matched pair analysis. Oral Oncology, 59. pp. 80-85. ISSN 1368-8375
Abstract
Objectives: The purpose of this matched pair analysis is to assess patient-reported long term swallow function following chemoradiotherapy for locally advanced oropharyngeal cancer in relation to the use of a prophylactic gastrostomy or reactive nasogastric (NG) tube. Materials and methods: The MD Anderson Dysphagia Inventory (MDADI) was posted to 68 consecutive patients with stage III/IV oropharyngeal squamous cell carcinoma who had completed parotid sparing intensity modulated radiotherapy with concurrent chemotherapy between 2010 and 2012, had not required therapeutic enteral feeding prior to treatment, minimum 2 years follow up post treatment, and who were disease free. 59/68 replies were received, and a matched pair analysis (matching for T and N stage) was performed for 52 patients, 26 managed with a prophylactic gastrostomy and 26 with an approach of an NG tube as needed. Results: There were no significant differences in patient demographics, pre-treatment diet and treatment factors between the two groups. Patient-reported swallowing function measured using the MDADI was superior for patients managed with an NG tube as required compared with a prophylactic gastrostomy: overall composite score 68.1 versus 59.4 (p = 0.04), global score 67.7 versus 60 (p = 0.04), emotional subscale 73.5 versus 60.4 (p < 0.01), functional subscale 75.4 versus 61.7 (p < 0.01), and physical subscale 59.6 versus 57.1 (p = 0.38). Conclusions: Compared with an approach of an NG tube as required, the use of a prophylactic gastrostomy was associated with inferior long term patient-reported long term swallow outcomes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Head and neck cancer; Oropharynx cancer; Radiotherapy; Chemotherapy; Swallow; Late toxicity; Quality of life; Gastrostomy; Nasogastric tube |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Oncology and Cancer Research - Labs (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Dec 2016 11:42 |
Last Modified: | 20 Dec 2016 11:54 |
Published Version: | https://doi.org/10.1016/j.oraloncology.2016.06.007 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.oraloncology.2016.06.007 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:109627 |