Zhang, F, Liu, T, Huo, Y et al. (2 more authors) (2017) Investigation of the operating conditions to morphology evolution of β-l-glutamic acid during seeded cooling crystallization. Journal of Crystal Growth, 469. pp. 136-143. ISSN 0022-0248
Abstract
In this paper the effects of operating conditions including cooling rate, initial supersaturation, and seeding temperature were investigated on the morphology evolution of β-l-glutamic acid (β-LGA) during seeded cooling crystallization. Based on the results of in-situ image acquisition of the crystal morphology evolution during the crystallization process, it was found that the crystal products tend to be plate-like or short rod-like under a slow cooling rate, low initial supersaturation, and low seeding temperature. In the opposite, the operating conditions of a faster cooling rate, higher initial supersaturation, and higher seeding temperature tend to produce long rod-like or needle-like crystals, and meanwhile, the length and width of crystal products will be increased together with a wider crystal size distribution (CSD). The aspect ratio of crystals, defined by the crystal length over width measured from in-situ or sample images, was taken as a shape index to analyze the crystal morphologies. Based on comparative analysis of the experimental results, guidelines on these operating conditions were given for obtaining the desired crystal shapes, along with the strategies for obtaining a narrower CSD for better product quality. Experimental verifications were performed to illustrate the proposed guidelines on the operating conditions for seeded cooling crystallization of LGA solution.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 Elsevier B.V. This is an author produced version of a paper published in Journal of Crystal Growth. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Seeded cooling crystallization; Morphology evolution; L-Glutamic acid; Operating conditions; Crystal shape; Aspect ratio |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Dec 2016 15:10 |
Last Modified: | 20 Sep 2017 06:44 |
Published Version: | https://doi.org/10.1016/j.jcrysgro.2016.09.041 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jcrysgro.2016.09.041 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:109316 |